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L-Citrulline

L Citrulline is an alpha amino acid that is a key intermediate in the urea cycle, the pathway by which mammals excrete ammonia from the body. [1]  L-Citrulline was first isolated from watermelon. Watermelon is named as citrullus in latin and hence it is also named as citrulline. L citrulline is tak as nutritional supplement because L form is more compatible to living protein and hence are useful when taken as dietary supplements. [2] Citrulline inside the body is made from ornithine in urea cycle and it is the precursor of another useful amino acid L arginine. [1, 2, 3]

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Functions of L-Citrulline

  • It is found in numerous protein include myelin basic protein (MBP), filaggrin, and several histone proteins. [1]  
  • L-Citrulline promotes energy production. [2]
  • L-Citrulline supports defense mechanism of body. [2]
  • L-Citrulline is an amino acid that has beneficial effects on body during fatigue. [2]
  • L-Citrulline found primarily in liver and detoxifies ammonia that can damage living liver. [2]  
  • Recently it is found that citrulline has same ability to relax blood vessels. [1]  
  • It may act as a vehicle that taking nitrogen to the muscle either directly or may be through conversion in to L- arginine.  [3]
  • Citrulline enhances production of protein in body, directly as well as L arginine. [3]
  • Citrulline along with arginine and ornithine improves exercise performance. [3]

References

  1. http://en.wikipedia.org/wiki/Citrulline
  2. Phyllis A. Balch, CNC & James F. Balch, M.D. (2000). Prescription for Nutritional Healing. (3rd edition) Page No. 44, 46. Penguin Putnam INC. New York: Avery.
  3. http://www.newworldencyclopedia.org/entry/Arginine
  4. http://books.google.com/books?id=nbR80wOZGz8C&pg=PA259&dq=citrulline#v=onepage&q=citrulline&f=false

Disclaimer

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, cure, mitigate, treat, or prevent any disease.


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