L-Citulline

L-Citrulline is an amino acid involved in the urea cycle and liver detoxification. L-Citrulline supplement supports the body in optimizing blood flow through its conversion to L-arginine and then nitric oxide.

L-Citrulline products also boosts energy and stimulates the immune system. Citrulline, which is considered a non-essential amino acid synthesized in the intestinal tract from Glutamine, converts to Arginine in the endothelial cells. This biochemical process involves L-Aspartate and the enzymes Argininosuccinate Synthetase and Argininosuccinate Lyase, in the presence of ATP. Arginine is important for Nitric Oxide production for cardiovascular health; however, most Arginine is utilized in the liver and kidneys, and only a fraction is available for this purpose. Since Citrulline is a precursor to Arginine, it allows for increased and sustained Nitric Oxide production in the endothelium for support of circulatory function.

Related Products
L-Citrulline by Now Foods As Low As: $14.78	L-Citrulline by Source Naturals As Low As: $19.53

Oral Citrulline supplementation provides a readily available source of Citrulline for this purpose, and some recent research further indicates that Citrulline supplement may be the preferred source of cellular Arginine. In addition Citrulline product also increases energy, stimulates the immune system, and is essential for Urea Cycle function as well.

L-Citrulline Made From and Urea cycle function:

L-Citrulline Made From:

L-Citrulline product is made from ornithine and carbamoyl phosphate in one of the central reactions in the urea cycle. It is also produced from arginine as a by-product of the reaction catalyzed by NOS family. First arginine is oxidized into N-hydroxyl-arginine, which is then further oxidized to L-Citrulline concomitant with release of nitric oxide.

L-Citrulline Urea cycle function:

The Urea Cycle functions to remove toxic ammonia by converting it to Urea (primarily in the liver). Ammonia is a highly toxic substance synthesized from protein and amino acid catabolism, and is also formed in the intestinal tract. It is extremely high in liver disease and contributes significantly to hepatic failure.

The Urea cycle functions in a complicated biochemical process in which Ornithine, Citrulline, Aspartic Acid, Argininosuccinate Acid, Fumeric Acid, and Arginine, along with the necessary enzymes and Carbon Dioxide convert ammonia to Urea. All of these are components and function as the Urea cycle.

How L-Citrulline Works?

L-Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain L-Citrulline. These L-Citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert Arginine into L-Citrulline in a process called citrullination or deimination. Proteins that normally contain L-Citrulline residues include myelin basic protein (MBP), filaggrin and several histone proteins, while other proteins, like fibrin and vimentin can get citrullinated supplements during cell death and tissue inflammation.

Use of L-Citrulline Products.