| Product Description |
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Benefits
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Maximum strength digestive enzymes to help
your body break down fats, carbohydrates, and proteins in the small
intestines. |
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Supports digestion when taken with meals. |
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Promotes joint and immune health when taken
between meals. |
Key Features
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The highest potency pancreatic enzyme complex
available. |
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Combination of plant and animal-sourced
enzymesmost similar to your bodys natural enzymes. |
Support your diet with the highest potency pancreatic enzyme complex available. Contains no salt or lactose like other products - just full strength pancreatic extract with natural proteolytic enzymes from both plant and animal sources. This formula helps your body break down fats, carbohydrates, and proteins in the small intestines.
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| Suggested Use
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| Two tablets before each meal.
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| Ingredients/Supplement Facts
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| Supplement Facts |
Serving Size: 2 Tablets |
| Ingredients |
Amount |
%DV |
Pancreatic Enzymes10X
USP units of activity:
Protease 81,250
Amylase 81,250
Lipase 6,500 |
325 mg |
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| Trypsin |
75 mg |
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| Papain |
50 mg |
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| Bromelain (1,200 M.C.U./g) |
50 mg |
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| Amylase |
10 mg |
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| Lipase |
10 mg |
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| Lysozyme |
10 mg |
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| Chymotrypsin |
2 mg |
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| Other
Ingredients:cellulose, potassium bicarbonate, modified cellulose gum, modified cellulose, magnesium stearate, lecithin, and carnauba wax. |
Contains No: sugar, salt, yeast, wheat, gluten, corn, dairy products, artificial coloring, artificial flavoring and preservatives. This product contains natural ingredients; color variations are normal.
: Daily value not established.
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| Additional Information |
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| Introduction:
An enzyme is any of various types of proteins which act as catalysts to speed up
the body's biochemical processes. Enzymes build new proteins, cells, tissues,
and organs, and can also break down these same tissues. All living organisms
contain enzymes - without them, life could not exist.
Digestive enzymes are a group of specific enzymes in the gastrointestinal tract
which function to break down the components of food. While digestive enzymes are
also produced in the mouth (in saliva) and the stomach, the area of greatest
digestive enzyme activity is in the small intestine.
A key organ in digestive enzyme production is the pancreas. Up to 1.5 quarts of
pancreatic juice, containing digestive enzymes to break down carbohydrates, fat
and protein, is secreted by the pancreas into the small intestine every day. The
major pancreatic enzymes are known as lipases, amylases, and proteases
(including trypsin, chymotrypsin and carboxypeptidase).
Supplemental enzymes, particularly pancreatic digestive enzymes, have a long
history of traditional use.5 In addition to digestive support, pancreatic
enzymes have been recommended for immune system support, to support urinary
tract health, lung health, and for the relief of occasional pain and
inflammation associated with exercise.
How Does It Work?:
Enzymes have specificity, meaning they act only on
their specific substrates. For example, the digestive
enzyme
amylase acts on carbohydrates, lipase on fats, and protease on protein.†
Therefore, to obtain greater benefits, a digestive enzyme supplement should
include a range of enzyme types. Mega-Zyme systemic enzymes contains
eight key enzymes, plus 10X pancreatic enzymes for maximum digestive support.
10X strength refers to a high potency (10X) pancreatic enzyme complex which is
10 times more potent than the minimum activity specified by the United States
Pharmacopiea (USP).
The ingredients in Mega-zyme systemic enzymes are buffered with
bicarbonate. Bicarbonates help to neutralize the acid environment of the stomach
and allow the digestive enzymes to work in the small intestine. Normal pH of the
stomach is 2 (acidic) while pancreatic juice is about 8 (basic). Bicarbonates
assist in changing the acidic environment to an alkaline environment.†
The bicarbonates in Mega-Zyme systemic enzymes are designed to work with
the other ingredients to support a healthy digestive system.
Mega-Zyme systemic enzymes was also used in several clinical trials
demonstrating its benefits for relieving muscle pain and inflammation associated
with exercise.†7-9 In comparison with the placebo group, athletes
taking Mega-Zyme systemic enzymes before and after intense exercise had
less muscle pain and faster recoveries.
The following chart summarizes the activity of each of the enzymes in Mega-Zyme
systemic enzymes.
Enzyme
Substrate
Action
Source
Protease
Protein
Cleaves polypeptide chains†10
Porcine
Amylase
Carbohydrates
Breaks down starch to maltose and
dextrin†11
Porcine and
Aspergillus oryzae
Lipase
Lipids (fats)
Degrades fats to glycerol and fatty
acids†12
Porcine and
Rhizopus Oryzae
Trypsin
Protein
Hydrolyzes peptides, amides, esters,
etc at the bonds of the carboxyl groups of L-arginine or L-lysine†13
Porcine
Papain
Protein
Catalyzes the hydrolysis of proteins
and peptides with preferential cleavage at bonds containing arginine,
lysine, and glycine residues†14
Papaya
Bromelain
Protein
Hydrolyzes proteins to oligopeptides and
amino acids†15
Pineapple
Lysozyme
Starch (initiates breakdown)
Hydrolyses the bond between N acetyl
muramic acid and N acetyl glucosamine†16
Egg
Chymotrypsin
Protein
Cleaves carboxyl links of hydrophobic
amino acids†17
Bovine
References:
1. Pancreas. In: Thomas CL, d. Taber's
Cyclopedic Medical Dictionary. 17th ed. Philadelphia, Pa: F.A. Davis;
1993:1414.
2. Guton AC, Hall JE. Secreotry Functions of
the alimentary Tract. In: Textbook of Medical Physiology. 9th ed.
Philadelphia, Pa: WB Saunders Company; 1996: 824-825.
3. Gastrointestinal Function. In: Porth CM.
Pathophysiology. 5th ed. Philadelphia, Penn: Lippincott-Raven Publishers;
1988:714-715.
4. Enzymes. In: Thomas CL, ed. Taber's
Cylcopedic Medical Dictionary. 17th ed. Philadelphia, Pa: F.A. Davis;
1993:645-655.
5. Cichoke AJ. Pancreatic enzymes. In:
Textbook of Natural Medicine. Pizzorno JE, Murray MT, eds. Edinburgh:
Churchill Livingstone; 1993:857.
6. Whitney EN, Rolfes SR. Digestion,
Absorption, and Transport. In: Understanding Nutrition. 6th ed. St. Paul,
MN: West Publishing Company; 1993:73-74.
7. Miller PC, et al. The effects of protease
supplementation on skeletal muscle function and DOMS following downhill running.
J Sports Sci. 2004 Apr;22(4):365-72.
8. Miller PC, Bailey SP, McInnis KR, Hall EE.
Comparison of protease and NSAID supplementation on muscle soreness and pain
threshold following downhill running. Med Sci Sports Exerc.
2003:35(5Supplement):S197.
9. Miller PC, Bailey SP, Cormier S, Khlebopros
A, Hall EE. Comparison of protease and NSAID supplementation on muscle soreness
and contractile performance following eccentric contractions. Med Sci Sports
Exerc. 2002;34(5):S232.
10. Protease. Department of Plant Pathology
Online Glossary. Cornell University. Available at:
http://ppathw3.cals.cornell.edu/glossary/Defs_P.htm. Accessed June 28, 2006.
11. Amylase. The Merck Index: An
Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ:
Merck & Co., Inc.1996:102.
12. Lipase. The Merck Index: An Encyclopedia
of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck & Co.,
Inc.1996:941.
13. Trypsin. Stedman's Medical Dictionary,
25th ed. Baltimore: Williams and Wilkins; 1990:1644.
14. Papain. Medical Dictionary. Available at
www.mercksource.com. Accessed June 28, 2006.
15. Bromelain. In: Fleming T, ed. PDR® for
Nutritional Supplements. Montvale, NJ: Medical Economics Company;
2001:70-73.
16. Lysozyme. Stedman's Medical Dictionary,
25th ed. Baltimore: Williams and Wilkins; 1990:908.
17. Chymotrypsin. Stedman's Medical
Dictionary, 25th ed. Baltimore: Williams and Wilkins; 1990:306.
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