| Product Description |
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| Benfotiamine (S-benzoylthiamine-O-monophosphate) is a synthetic derivative of thiamin, belonging to the family of compounds known as "allithiamines." Benfotiamine is fat-soluble and thus more bioavailable and physiologically active than thiamin.* Characteristic of the allithiamines is an open thiazole ring within the chemical structure of these thiamine-related compounds, making them fat (lipid) soluble. In contrast, thiamine, which is water soluble, has a closed thiazole ring. The lipid solubility of benfotiamine, conferred by this open ring, increases its bioavailablity. Benfotiamine is readily absorbed at higher doses, in contrast to absorption of water-soluble thiamin salts, which decreases at higher doses, due to saturation of absorption sites in the intestines.
1 In a double-blind, cross-over trial, comparing bioavailability of benfotiamine to that of thiamine in 12 subjects, benfotiamine caused an average 5-fold greater increase in blood thiamine levels than thiamin mononitrate, with a concomitant greater thiamine concentration in erythrocytes (red blood cells).
2 Benfotiamine readily passes through intestinal mucosal cells, where it is converted into physiologically active thiamine. Benfotiamine inceases blood levels of thiamine pyrophosphate (TPP), the primary thiamin co-enzyme.
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| Suggested Use |
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| Suggested Adult Use: One capsule daily, with or without food
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| Ingredients/Supplement Facts |
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| Supplement Facts |
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| Ingredients |
Amount |
%DV |
| benfotiamine |
150 mg |
† |
†: Daily value not established.
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| Additional Information |
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Benefits
Benfotiamine raises the blood level of thiamine pyrophosphate (TPP), the
biologically active co-enzyme of thiamine.4*
Thiamine and its Co-enzyme, TPP
Thiamine (vitamin B1) plays an essential part in the metabolism of glucose,
through actions of it co-enzyme TPP (thiamine pyrophosphate). More information about Best Benfotiamine |
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| Disclaimer |
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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, cure, mitigate, treat, or prevent any disease.
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